Lassen Therapeutics is a therapeutic antibody discovery and development company dedicated to the identification of novel medicines for serious unmet medical needs. We are currently recruiting for a highly motivated and enthusiastic Research Associate/Senior Research Associate to join our lab-based team in San Diego.
In this role, you will help advance our therapeutic pipeline in tissue fibrosis, inflammation and oncology. This position will be responsible for developing and conducting in vitro and ex vivo functional and translational assays to understand disease biology and evaluate the efficacy and potency of candidate therapeutic antibodies. You will bring a research background in cell biology, preferably with expertise in inflammation and immunology. You will have experience in cell signaling assays, primary cell culture and human tissue models, and ideally experience with additional techniques such as cell transfection, flow cytometry, ELISA, Western blot, PCR and immunofluorescence microscopy. The position will report to our V.P. of Fibrosis and Translational Biology and be expected to work effectively with limited supervision but within a team setting.
Responsibilities
- Perform in vitro cellular functional and signaling assays using primary mouse and human cells and cell lines to evaluate disease relevant pathways and the cellular activity of candidate therapeutic antibodies against specific targets.
- Optimize and perform cell signaling, ELISA, immunofluorescence, PCR, protein expression and flow cytometry assays.
- Produce, maintain, and archive stably transfected cell lines and cells used in functional assays.
- Design and accurately execute experiments, analyze and interpret experimental results contributing to research program strategies.
- Develop an expanding technical and theoretical knowledge base in cellular biology and reflecting a growing understanding of the scientific literature.
- Organize, summarize and present data to supervisor and at project team meetings.
- Interact actively with other members of the research team to address scientific questions.
- Prepare technical reports, summaries, and detailed protocols.
- May contribute to scientific journals.
Requirements and Qualifications
- BA/BS in biology-related discipline and 4-6 years of industry laboratory experience.
- Knowledge of in vitro and ex vivo models of fibrosis and inflammation; In vivo experience is a plus.
- Ability to work both collaboratively and independently.
- Basic knowledge of principles and practices of cell biology and cellular immunology, including mammalian cell culture, cell transfection, functional cellular and immunofluorescence and cellular assay development.
- Experience and understanding of routine in vitro screening assays, fibrosis/tissue remodeling assays and 3D cell and/or tissue culture assays is a plus.
- Ability to work with and isolate cells from explanted normal and human diseased tissue.
- Ongoing knowledge of research developments and literature within the fibrosis, inflammation and oncology space.
- Proficiency in data analysis and presentation applications including Microsoft Word, Excel, PowerPoint and Graphpad Prism.
- Ability to communicate clearly, and to report and present experimental results and analysis to supervisor, department colleagues, and at project team meetings.
- Strong written and oral skills and excellent interpersonal skills.
- Team player with the ability to collaborate effectively with colleagues, intensely committed to success and getting the job done well in a highly dynamic and exciting environment.
- Ability to multitask, prioritize and work within schedules and deadlines.
- Excellent organizational skills with strong attention to detail.
This position is an onsite, full time, direct hire, lab based role.
Lassen Therapeutics offers a competitive benefits package including medical, dental, vision and life insurance benefits for employees and their families. We also offer a 401(k) plan with a matching contribution, stock equity, unlimited time off and more.
Lassen is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other protected category.